Malaria proguanil and chloroquine

Discussion in 'Trusted Online Pharmacy' started by OrangE, 25-Feb-2020.

  1. zsulxp XenForo Moderator

    Malaria proguanil and chloroquine


    In a randomized, open-label, multicenter prophylaxis trial, 221 nonimmune pediatric travelers (age, 2–17 years) received either atovaquone-proguanil or chloroquine-proguanil. Safety and clinical outcome were evaluated 7, 28, and 60 days after travel.

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    Malaria parasites in the red blood cells are killed more rapidly by chloroquine or quinine than by proguanil, which is therefore not the best drug to use for the treatment of acute malaria. Soon after proguanil was introduced, it was observed that the drug was inactive as an inhibitor of the in vitro growth of p. Chloroquine and mefloquine are to be taken once weekly, beginning 1 week before entering the malarial area, during the stay and for 4 weeks after leaving. Doxycycline and proguanil are taken daily, starting 1 day before entering malarial areas, during the stay, and for 4 weeks after departure. Mefloquine is the agent of choice for chloroquine-resistant areas, and evidence suggests it is not associated with an increased risk to the fetus. Although the atovaquone-proguanil drug combination is not currently recommended for use during pregnancy, limited data suggest that it is not harmful to the fetus.

    The data indicate that, over the course of treatment, fewer atovaquone-proguanil recipients had treatment-related adverse events (8% vs. Two subjects discontinued prophylaxis because of drug-related adverse events; both had received chloroquine-proguanil. By posttravel day 7, a total of 39 (35%) of 110 atovaquone-proguanil and 41 (37%) of 111 chloroquine-proguanil recipients reported ⩾1 adverse event.

    Malaria proguanil and chloroquine

    Proguanil and Chloroquine - NPA NPA, Chloroquine Plus Proguanil - an overview ScienceDirect Topics

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    The present study was designed to compare the safety profile of atovaquone-proguanil with that of chloroquine-proguanil in healthy nonimmune children traveling to regions where malaria is endemic. Both treatment regimens were generally well tolerated, with no apparent difference in the number of subjects reporting adverse events from the start of travel through day 7 after travel. Chloroquine is the drug of choice in the few malaria-endemic areas free of CRPf. Combining chloroquine and proguanil is an option for CRPf when other first-line antimalarials are contraindicated. Dosage should be calculated in terms of the base. The adult chloroquine dose is 300 mg base weekly or in some countries 100 mg base daily. Prevention of Malaria. Atovaquone and Proguanil hydrochloride tablets are indicated for the prophylaxis of Plasmodium falciparum malaria, including in areas where chloroquine resistance has been reported. Treatment of Malaria. Atovaquone and Proguanil hydrochloride tablets are indicated for the treatment of acute, uncomplicated P. falciparum malaria. Atovaquone and Proguanil hydrochloride.

     
  7. dekoroman XenForo Moderator

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    Hydroxychloroquine se usa en el tratamiento o prevención de malaria, una enfermedad causado por los parasitos que entran al cuerpo a través de la mordida de un zancudo. Hidroxicloroquina Plaquenil Hydroxychloroquine Información Española De la Droga Plaquinol Qué es, usos, efectos secundarios.
     
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