I've stopped Sulfa as I was experiencing a bad taste & smell, which may be caused by sulfa. After a while it wasn't as effective and I too was prescribed methotrexate alongside. I'm about to start MTX & am hoping that I wont have side effects with that! The side effects of the methotrexate for me were horrendous (chronic chest infections) and I'm now asthmatic as a result. Plaquenil and burning eyes Mucinex and plaquenil Puckering of tongue plaquenil Hydroxychloroquine Plaquenil and sulfasalazine Azulfidine are used for mild rheumatoid arthritis. They are not as powerful as other disease-modifying antirheumatic drugs, but they usually cause fewer side effects. May 28, 2016 I have been diagnosed with Limited Scleroderma. My choices are Methotrexate, Plaquenil or Sulfasalzine Azulfidine. I researched them and determined Plaquenil would be my last choice, although it was his first, because I already have lattice degeneration of the retina in both eyes and one of the potential side effects is retinal problems. If the plaquenil is helping and they say you need it, I'd take it - the side effects will go away. I've not had experience with sulfasalazine - but from what I've read, the side effects of that med are about the same as those of plaquenil. BTW - sulfasalazine is an anti-inflammatory. I had side effects from MTX, which largely wore off, but haven't had any problems with the Hydroxy or Sulpha. I refuse to take it now even if its my passport to biologic treatment. I started with MTX which worked, but not enough so the others were added in which has been better. Plaquenil and sulfasalazine Sulfasalazine Oral Route Precautions - Mayo Clinic, Methotrexate, Plaquenil or Sulfasalazine Azulfidine. Skin cancer side effect of plaquenilHydroxychloroquine client edChloroquine ifn signatureSide effects of hydroxychloroquine medicationPlaquenil cardiac side effects Jun 09, 2006 However, hydroxychloroquine has an extremely favorable toxicity profile and is widely considered to be safe to use in the perioperative period as it is not a potent immunosuppressant. Leflunomide, sulfasalazine, and azathiaprine all have immunosuppressive properties and can be toxic at high levels. Perioperative Management of Medications Used in the Treatment.. Plaquenil and sulfasalazine - Autoimmune Disorders - MedHelp. Hydroxychloroquine - an overview ScienceDirect Topics. However, hydroxychloroquine has an extremely favorable toxicity profile and is widely considered to be safe to use in the perioperative period as it is not a potent immunosuppressant. Leflunomide, sulfasalazine, and azathiaprine all have immunosuppressive properties and can be toxic at high levels. So she is having me start sulfasalazine---- do any of you take this and even better do any of you take this along with plaquenil and/or prednisone because until I can wean myself off the awful prednisone I will be taking all three medicines. Hydroxychloroquine is sometimes combined with methotrexate for additive benefits for signs and symptoms or as part of a regimen of “triple therapy” with methotrexate and sulfasalazine. Mechanism The mechanism of action of antimalarials in the treatment of patients with rheumatoid arthritis is unknown but is thought to involve changes in.