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Either you supplied the wrong credentials (e.g., bad password), or your browser doesn't understand how to supply the credentials required. Here’s a forgotten chapter from pharmaceutical history. The acne drug, Accutane (isotretinoin), manufactured by Roche Pharmaceuticals, in addition to being associated with (as I wrote in prior posts) suicide, depression, and aggression, has been associated with hundreds of birth defects. Since 2005 the i PLEDGE program has required that patients, doctors, and pharmacists register and that patients prove they are on birth control before they can be prescribed this potentially dangerous drug. When Accutane came out on the American market, after being rushed through the FDA approval process, it was listed as a category C drug for risk of birth defects, meaning that it was only of moderate risk. The PDR said that women should not get pregnant while on Accutane. 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