They're a class of painkillers known as non-steroidal anti-inflammatories (NSAIDs) and we take them to relieve a wide range of conditions from headaches and period cramps to arthritis. Recent research linking them with an increased risk of stroke received widespread publicity. Since most of us take these medicines at some time or another, how worried do we need to be? In Australia, NSAIDs include both prescription and over-the-counter medicines, such as: The research highlighting stroke risk was done in Denmark (where NSAIDs are available exclusively on prescription) and covered all of these NSAID types. It looked at about 450,000 people (median age 39) who had filled at least one prescription for a NSAID over a nine-year period. It found all the anti-inflammatory types were associated with an increased risk of fatal or nonfatal stroke, but different medicines carried different levels of risk. 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They need to know if you have any of these conditions: -asthma -coronary artery bypass graft (CABG) surgery within the past 2 weeks -drink more than 3 alcohol-containing drinks a day -heart disease or circulation problems like heart failure or leg edema (fluid retention) -high blood pressure -kidney disease -liver disease -stomach bleeding or ulcers -an unusual or allergic reaction to celecoxib, sulfa drugs, aspirin, other NSAIDs, other medicines, foods, dyes, or preservatives -pregnant or trying to get pregnant -breast-feeding Take this medicine by mouth with a full glass of water. Take it with food if it upsets your stomach or if you take 400 mg at one time. Try to not lie down for at least 10 minutes after you take the medicine. Do not take more medicine than you are told to take. 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