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    Clonidine 0.15 mg


    Each 1 ml ampoule contains 0.15 mg clonidine chlorhydrate. To be adjusted according to physiopathologic status, desired and obtained clinical results. The drop in blood pressure should not exceed 25 % of the initial value, in the hour following initiation of injectable treatment. Average dose: 3-4 ampoules/day i/m or infusion route.-- i/m route: 1 ampoule may be injected every 4 hours according to observed clinical results and switch to oral treatment will be necessary.i/m route is not adapted for pre-eclampsia treatment.-- i/v infusion: usually 4 ampoules diluted in 500 ml of a 5 % glucose solution, ie 1.2 µg/ml:- starting dose: 1.2 µg/min, ie 20 drops/min;- maximum dose: 7.2 µg/min, ie 120 drops/min. At the end of perfusion, either reduce dosage gradually or switch to oral treatment.-- i/v route: dilute the contents of 1 ampoule in 10 ml of normal saline. May be injected by slow i/v injection (7-10 minutes). Injection may be repeated every 4 hours if needed.-- Renal impairment: careful dose adjustment required. clonidine narcotic withdrawal PO administration: 0.1-0.3 mg q4-6hr; increase by 0.1 mg/day to 0.15-0.75 mg/day if required; do not exceed 2.4 mg/day TD administration: 100-200 mcg/day patch q7Days; initiate 0.1-0.3 mg PO q4-6hr for first 2 days to allow for adequate drug levels Not recommended as routine treatment for hypertension (Beers criteria) Potential for orthostatic hypotension and adverse CNS effects May cause bradycardia Immediate release: Lower initial doses than for nongeriatric adult dosing, as well as gradual adjustments, are recommended Extended release: May require lower initial dose than for nongeriatric adult dosing Skin reactions; patch (15-50%) Dry mouth (40%) Somnolence (19-38%) Headache (19-29%) Fatigue (13-24%) Drowsiness (33%) Dizziness (13-16%) Hypotension, epidural (45%) Postural hypotension, epidural (32%) Anxiety (11%) Epidural clonidine is not recommended for obstetric postpartum or perioperative pain management because the risk of hemodynamic instability (eg, hypotension, bradycardia) may be unacceptable in this population Dilute product with strength of 500 mcg/m L prior to use Epidural: Hemodynamically unstable patients (risk of severe hypotension) Do not discontinue suddenly (risk of rebound hypertension) Patch: May need to remove if severe erythema and/or localized vesicle formation develop at application site or generalized rash; consult physician Severe coronary insufficiency May cause xerostomia Recent MI Cerebrovascular disease Chronic renal failure Raynaud's disease Thromboangiitis obliterans History of depression (may exacerbate depression in cancer patients) May impair ability to perform hazardous tasks Remove patch before MRI (may cause burns) Hypotension may occur; usually responsive to IV fluids and, if necessary, appropriate parenterally administered pressor agents Cardiac conduction abnormalities: Sympatholytic action may worsen sinus node dysfunction and atrioventricular (AV) block, especially if coadministered with other sympatholytic drugs Titrate slowly and monitor vital signs frequently in patients at risk for hypotension, heart block, bradycardia, syncope, cardiovascular disease, vascular disease, cerebrovascular disease or chronic renal failure; measure heart rate and blood pressure prior to initiation of therapy, following dose increases, and periodically while on therapy; avoid concomitant use of drugs with additive effects unless clinically indicated; advise patients to avoid becoming dehydrated or overheated Epidural administration may result in mild respiratory depression (usually with higher than recommended dose) Use with caution in cerebrovascular disease Avoid as first line antihypertensive in the elderly due to high risk for adverse side effects Children may be particularly susceptible to hypertensive episodes when experiencing GI illnesses that lead to vomiting Discontinue oral immediate release formulations within 4 hr of surgery; restart as soon as possible following surgery Due to different pharmacokinetic profiles, oral formulations are not interchangeable with extended release on a mg-mg basis due to different pharmacokinetic profiles Central sympatholytic via stimulation of central alpha receptors; results in reduced sympathetic outflow, causing decreased PVR, HR, BP, and renal vascular resistance; produces presynaptic and postjunctional alpha-2 adrenoreceptor analgesia by preventing pain signal transmission to brain Postsynaptic alpha2-agonist stimulation may regulate subcortical activity in the prefrontal cortex, which may regulate the area of the brain responsible for attention, emotions, and behaviors, and thereby reduces hyperactivity, distractibility, and impulsiveness The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

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    Clonidine Hydrochloride 0.15 MG Oral Tablet. Synonyms. cloNIDine HCl 0.15 MG Oral Tablet. ID. valacyclovir and pregnancy The clonidine is an agonist of imidazolinovy receptors. Use of a clonidine leads to decrease in heart rate, systolic and diastolic arterial pressure, and also general peripheral vascular resistance. Kontraindikasi Clonidine 0,15 Mg Tab 100s/g sindroma sick-sinus Peringatan dan Perhatian Clonidine 0,15 Mg Tab 100s/g Tidak ada Efek Samping Clonidine 0,15 Mg Tab 100s/g mulut kering, sedasi, rasa lelah Dosis dan Pemberian Clonidine 0,15 Mg Tab 100s/g tab awal 0.075 - 0.15mg/hr, dpt ditingkatkan setelah 2-4 minggu. Hipertensi berat dpt.

    After passing through a blood-brain barrier the clonidine selectively stimulates 2 adrenoceptors of kernels of a vasomotor center of a myelencephalon at the expense of what brakes a sympathetic impulsation from the central nervous system, causing a vazodilatation and a lowering of arterial pressure. Decrease in sympathetic activity is followed by lowering of the level of catecholamines (especially noradrenaline) in a blood plasma and urine though the clonidine has no direct effect on synthesis of catecholamines, and release of noradrenaline from nerve terminations on a negative feedback mechanism as a result of stimulation of the central 2 adrenoceptors diastolic arterial pressure, and also general peripheral vascular resistance. The minute volume of blood and a stroke output of heart decrease slightly. Prolonged use of a clonidine leads to reduction of a hypertrophy of a myocardium and improvement of function of a left ventricle. The clonidine has sedative and moderate analgeziruyushchy effect. Due to the central action it is capable to eliminate somatovegetativny manifestations of opiate and alcoholic abstinence. The clonidine lowers intraocular pressure due to reduction of secretion and improvement of outflow of watery moisture of an eye. Usual dose range is 0.2 to 0.6 mg daily in divided doses. If transdermal patch is used, apply to area of hairless intact skin once q 7 days. Half-life of clonidine ranges from 6 to 20 hours in patients with normal renal function. b.i.d.; then increased by 0.1 per day at weekly intervals until desired response is achieved. Excretion: About 65% of a given dose is excreted in urine; 20% is excreted in feces. Initially, clonidine may stimulate peripheral alpha-adrenergic receptors, producing transient vasoconstriction. Antihypertensive action: Clonidine decreases peripheral vascular resistance by stimulating central alpha-adrenergic receptors, thus decreasing cerebral sympathetic outflow; drug also may inhibit renin release. Or, apply transdermal patch (0.2 mg/24 hours) and replace weekly for the first 2 or 3 weeks after smoking cessation. After oral administration, the antihypertensive effect lasts up to 8 hours; after transdermal application, the antihypertensive effect persists for up to 7 days. Contraindicated in patients hypersensitive to drug. Transdermal form is contraindicated in patients hypersensitive to any component of the adhesive layer.

    Clonidine 0.15 mg

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  3. PO administration 0.1 mg qDay; increase by 0.1 mg/day to 0.15-0.75 mg/day if. Clonidine suppression testing 0.3 mg PO for 60-80 kg patient; obtain blood.

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