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    Is viagra a vasodilator


    Background: The cardiovascular effects of sildenafil (Viagra), a selective inhibitor of phosphodiesterase type 5 (PDE5), have been extensively studied. However, its effect on human retinal arteries and veins has not yet been investigated. The effect of a single dose administration of sildenafil on the retinal vessel diameters of healthy subjects was evaluated. Methods: Sildenafil 50 mg was administered to 10 healthy subjects (male:female = 4:6; mean age 31 (SD 6) years). The diameters of retinal arteries and veins were measured by means of a retinal vessel analyser (RVA) immediately before and at 30, 60, 90, and 120 minutes after sildenafil uptake. Blood pressure, heart rate, and intraocular pressure were monitored in parallel. Results: A significant increase of 5.8% (p Production of c GMP from guanosine triphosphate (GTP) is mediated through the nitric oxide (NO) signalling pathway. buy cialis professional 20 mg Viagra, the first medication produced to treat erectile dysfunction (ED) was approved in 1998. It quickly gained notoriety and is still the top selling prescription medication produced by the pharmaceutical giant Pfizer. In Viagra’s peak sales year of 2012, revenue from Viagra has been reported at over $2 billion with about 8 million prescriptions written. As many as 45 million men have used Viagra in its decade and a half lifespan. Viagra is the brand name of the generic medication sildenafil. It was first patented as a heart medication for angina but early clinical studies showed that it was not effective for that use. The studies also showed that it had a side effect – increased numbers of erections in men.

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The primary indication of sildenafil is treatment of erectile dysfunction (inability to sustain a satisfactory erection to complete intercourse). Its use is now one of the standard treatments for erectile dysfunction, including for men with diabetes mellitus. Rare but serious adverse effects found through postmarketing surveillance include prolonged erections, severe low blood pressure, myocardial infarction (heart attack), ventricular arrhythmias, stroke, increased intraocular pressure, and sudden hearing loss. Care should be exercised by people who are also taking protease inhibitors for the treatment of HIV infection. Protease inhibitors inhibit the metabolism of sildenafil, effectively multiplying the plasma levels of sildenafil, increasing the incidence and severity of side effects. Those using protease inhibitors are recommended to limit their use of sildenafil to no more than one 25 mg dose every 48 hours. blocker (typically prescribed for hypertension or for urologic conditions, such as benign prostatic hypertrophy) at the same time may lead to low blood pressure, but this effect does not occur if they are taken at least 4 hours apart.

    Is viagra a vasodilator

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