IV/IM: Initial dose: 20 to 40 mg IV (slowly over 1 to 2 minutes) or IM once; may repeat with the same dose or increase by 20 mg no sooner than 2 hours after the previous dose until the desired diuretic effect has been obtained. Maintenance dose: Administer the dose that provided the desired diuretic effect once or twice a day. Use: Treatment of edema associated with congestive heart failure, cirrhosis of the liver, and renal disease, including the nephrotic syndrome, especially when an agent with greater diuretic potential is desired. Oral: Initial dose: 20 to 80 mg orally once; may repeat with the same dose or increase by 20 or 40 mg no sooner than 6 to 8 hours after the previous dose until the desired diuretic effect has been obtained. Maintenance dose: Administer the dose that provided the desired diuretic effect once or twice a day (e.g., at 8 am and 2 pm). Maximum dose: 600 mg/day in patients with clinically severe edematous states Comments: -Edema may be most efficiently and safely mobilized by giving this drug on 2 to 4 consecutive days each week. -When doses greater than 80 mg/day are given for prolonged periods of time, careful clinical observation and laboratory monitoring are particularly advisable. can you buy clomid over the counter in uk Close medical supervision and dose evaluation are required. Watch for and correct electrolyte disturbances; adjust dose to avoid dehydration. When electrolyte depletion is present, therapy should not be initiated unless serum electrolytes, especially potassium, are normalized. In cirrhosis, avoid electrolyte and acid/base imbalances that might lead to hepatic Oral tablet: 47-64%; Oral solution: 60%; S. administration of tablet: ~60%; results of a small comparative study (n=11) showed bioavailability of SL administration of tablet was ~12% higher than oral administration of tablet ( may repeat the same dose or increase dose in increments of 20-40 mg/dose at intervals of 6-8 hours; usual maintenance dose interval is once or twice daily; may be titrated up to 600 mg/day with severe edematous states. injections may be administered at a rate of 20-40 mg per minute; maximum rate of administration for short-term intermittent infusion is 4 mg/minute; exceeding this rate increases the risk of Assess for allergy to sulfonylurea before beginning therapy. Initial: 20-40 mg/dose; if response not adequate, may repeat the same dose or increase dose in increments of 20 mg/dose and administer 1-2 hours after previous dose (maximum dose: 200 mg/dose). Assess potential for interactions with other pharmacological agents or herbal products patient may be taking (especially anything that may impact fluid balance, electrolyte balance, or increase potential for or hypotension). Assess results of laboratory tests (electrolytes), therapeutic effectiveness, and adverse response on a regular basis during therapy (, dehydration, electrolyte imbalance, postural hypotension). Individually determined dose should then be given once or twice daily although some patients may initially require dosing as frequent as every 6 hours. Caution patients with diabetes about closely monitoring glucose levels (glucose tolerance may be decreased). Initial: 1 mg/kg/dose; if response not adequate, may increase dose in increments of 1 mg/kg/dose and administer not sooner than 2 hours after previous dose, until a satisfactory response is achieved; may administer maintenance dose at intervals of every 6-12 hours; maximum dose: 6 mg/kg/dose I. 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Use cautiously in pregnant women, patients with sulfa allergy, and in those with hepatic cirrhosis. Duration of action is 6 to 8 hours after oral administration and about 2 hours after I. Contraindicated if increased azotemia, oliguria, or progressive renal disease occur during therapy. Diuresis begins in 30 to 60 minutes and peaks 1 to 2 hours after oral administration. Excretion: About 50% to 80% of a dose is excreted in urine; plasma half-life is about 30 minutes. Contraindicated in patients hypersensitive to drug and patients with anuria, hepatic coma, or severe electrolyte depletion. Increased by 20 mg q 2 hours until desired response is achieved. Food delays oral absorption but doesn’t alter diuretic response. administration within 5 minutes and peaks in 20 to 60 minutes. Absorption: About 60% of a dose is absorbed from the GI tract after oral administration. 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