A vardenafil az erektilis dysfunctioban szenvedő férfiak orális kezelésére szolgáló gyógyszer. Természetes körülmények között, azaz szexuális ingerre helyreállítja a zavart erekciós működést a penis vérátáramlásának fokozása révén. A szexuális stimulus nitrogén oxid felszabadulásához vezet. Aktiválja a guanil cikláz enzimet, amely a ciklikus guanozin monofoszfát (c GMP) szintjének emelkedéséhez vezet a corpus cavernosumban. Ez viszont simaizom ellazulást okoz, ami lehetővé teszi a fokozott vérbeáramlást a penisbe. A c GMP szintjét a guanil cikláz révén a szintézis üteme illetve a c GMP lebomlásának mértéke szabja meg a hidrolizáló foszfodieszterázok (PDE) útján. A vardenafil a c GMP-re specifikus 5 típusú foszfodieszteráz hatásos és szelektív gátlója, amely a corpus cavernosumban a legjelentősebb PDE. A vardenafil a PDE5 gátlása révén hatékonyan fokozza az endogén nitrogén oxid hatását a corpus cavernosumban. viagra gout Clinical Levitra efficacy has been shown during numerous and long drug investigations with thousands men participation. Everyone reported on significant erection improvement. Clinical researches have proved drug efficacy and safety. Levitra is used in men in many countries worldwide and the drug can make soon a competition to Viagra, the drug with undisputable efficacy. The erection under Levitra effect appears quickly and is characterized by strong and long action. However, drug action doesn't provide sexual excitation and doesn't increase sexual desire, therefore you see drug action only under natural excitation or sexual stimulation. Levitra is characterized by unique properties providing almost instant beginning drug action. The main target of Levitra is to increase the blood inflow to the penis. 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Film-coated tablet: 10 mg PO ~1 hour before sexual activity; may be increased to 20 mg or reduced to 5 mg, depending on effectiveness and tolerance; not to exceed 1 dose/day Orally disintegrating tablet (ODT): 10 mg PO placed on tongue ~1 hour before sexual activity; not to exceed 1 dose/day 10-mg ODT not interchangeable with 10-mg film-coated tablet; ODT provides higher systemic exposure at same dose; if higher or lower doses are required, film-coated tablet should be prescribed Anatomic deformation of penis, cardiovascular disease, left ventricular outflow obstruction, bleeding disorders, active peptic ulcer disease, liver disease, renal impairment, multidrug antihypertensive regimens, retinitis pigmentosa, conditions predisposing to priapism, concomitant use of CYP3A4 inhibitors Avoid in patients with congenital QT prolongation or those taking class IA or III antiarrhythmics Use in combination with other treatment for erectile dysfunction has not been studied and is not recommended Not to be taken with other phosphodiesterase (PDE)-5 inhibitors (eg, sildenafil, tadalafil) Concomitant use of alpha blockers increases risk of hypotension May increase risk of rare sudden vision loss attributed to nonarteritic ischemic optic neuropathy; if vision problems arise, discontinue, and contact physician Risk of sudden hearing loss Sexual stimulation causes nitric oxide to be released in corpus cavernosum, and nitric oxide activates guanylate cyclase, which in turn increases cyclic guanosine monophosphate (c GMP), thus causing smooth-muscle relaxation; PDE-5 inhibitors enhance smooth muscle-relaxing effects of nitric oxide in corpus cavernosum by inhibiting degradation of c GMP The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information. Vardenafil is used to treat male sexual function problems (impotence or erectile dysfunction-ED). In combination with sexual stimulation, vardenafil works by increasing blood flow to the penis to help a man get and keep an erection. This drug does not protect against sexually transmitted diseases (such as HIV, hepatitis B, gonorrhea, syphilis). Consult your doctor or pharmacist for more details. Read the Patient Information Leaflet provided by your pharmacist before you start taking vardenafil and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Take this medication by mouth as directed by your doctor, usually as needed. The dosage is based on your medical condition, response to treatment, and other medications you may be taking. Take vardenafil, with or without food, about 1 hour before sexual activity. 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