Those taking sertraline, also known under the brand name Zoloft, for major depressive disorder (MDD) should continue their regular prescribed dosage, even if they feel better. Missing doses of sertraline run the risk of relapsing into the symptoms being treated in the first place. Discontinuing sertraline abruptly can cause withdrawal symptoms like irritability, nausea, dizziness, vomiting, nightmares, headache and a prickly, tingling sensation on the skin known as paresthesias. Even without abrupt discontinuation of sertraline, withdrawal symptoms may still occur to some extent depending on the time span of use, dosage, individual physiology and the length of time taken to taper off sertraline. These include all the withdrawal symptoms above and may also include concentration problems, bouts of crying, depression, fatigue, diarrhea, memory problems, mood swings, suicidal thoughts and weight changes. 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Leslie's Amotivational Syndrome A Case of Fatigue and Apathy. Zoloft is a medication known as a selective serotonin reuptake inhibitor. The mediation is used to treat major depressive disorder, obsessive-compulsive disorder, panic disorder, post-traumatic stress disorder, social anxiety disorder, and premenstrual dysphoric disorder. Zoloft is a selective serotonin reuptake inhibitor (SSRI). SSRIs are the most commonly prescribed type of antidepressants, and they work by increasing levels of serotonin in the brain. They are also sometimes prescribed to treat anxiety and other conditions. If you have bipolar disorder and take an SSRI, you may be at risk for triggering a manic episode if you are not also taking a mood stabilizer. Talk to your doctor about your specific symptoms, other health concerns, and other medications you take so they can make the best recommendation for your condition and symptoms. 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